Fast Facts on Creatine and Its By- Product

Creatine is an important component of the muscle, and its by- product, creatinine, is produced when muscles increase energy. It is metabolized at a steady rate depending on the body’s muscle mass. It is usually removed from the blood as it goes through the kidneys.

Small amounts of it are actively secreted into the urine by the kidneys. Only about 1 to 1.8 grams are excreted by a normal adult in a day. The amount would also vary depending on several factors affecting muscle mass. Generally, men have increased levels than women because they have more skeletal muscle mass. Urine creatine by-product levels would also increase upon greater amounts of muscular activity.

Meanwhile, factors that could decrease levels in the urine would include muscular weakness and disorders associated with kidney functions. Increase of its level in the blood can indicate renal problems. When the kidneys start to malfunction, its levels would build up in the blood signaling a decrease in the efficiency of the kidneys to filter them out and excrete them through the urine. Together with urea, blood levels of by- products of creatine are essential indicators of renal function. Ratios among levels of these two substances can indicate other potential problems inherent to the kidneys.

Levels in the blood are obtained through a simple serum test. Normal levels would range from 0.6 to 1.2 mg/dl. Increased serum creatine levels suggest damage to the kidneys; however, it could not detect problems in early stages. Therefore, a clearance test is done by calculating serum concentrations against different variables like sex, age, weight, and the like out of urine samples collected in the whole 24 hours.

Concentration levels are also helpful in standard drug tests. Low creatine concentration in the urine could mean a manipulated test. Either water has been added to the sample or excessive amounts of fluids were taken in before the test was done or the sample was collected.

Harvin Gulfill is the editor of Protein pulver. Here you can also read more about Restitution.

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